Publications

Essays  •  Major Publications  •  Complete List of Publications  •  Reviews

Complete list of publications:

Original Reports:

  1. Lin ZJ, Wang JH, Fan HF. Crystal structure of L-pro-Gly. Science Bulletin 1965; 2:148-150.

  2. Beijing Insulin Structure Research Group. Studies on crystal structure of insulin at 2.5Å. Scientia Sinica (Chinese). 1972; 1:3-30.

  3. Beijing Insulin Structure Research Group. Studies on the insulin crytsal structure: The molecule at 1.8Å resolution. Scientia Sinica. 1974; 17:752-778.

  4. Wu BM, Wang JH. X-ray studies on two kinds of fibrous proteins from a cadaver preserved over 2000 years in a Han tomb. Scientia Sinica 1980; 23:915-922.

  5. Rubin JR, Wang JH. Sundaralingam M: X-ray diffraction study of the zinc (II) binding sites in yeast phenylalanine transfer RNA. Biochi. et Biophs. Acta. 1983; 756:111-114.

  6. Lewis M, Jeffrey A, Wang JH, Ladner R, Ptashne M, Pabo CO. Structure of the operator binding domain of lambda repressor: Implication for DNA recognition and gene regulation. Cold Spring Harbor Symp. Quant. Biol. 1983; 47:435-440.

  7. Wang JH*. How do proteins recognize DNA. Progress in Bicohem. and Biophys (China). 1984; 1:2-8.

  8. Stuart D, Dai JB, Lou MZ, You JM, Todd R, Li JY, Wang JH, Liang DC. X-ray studies on the structure of des-pentapeptide insulin at 2.4Å resolution—The refinement of the structure. Scientia Sinica 1984; 27:1265-1272.

  9. Stuart D, Dai JB, Lou MZ, You JM, Todd R, Li JY, Wang JH, Liang DC. X-ray studies on the structure of des-pentapeptide insulin at 2.4Å resolution.—Solution of the phase problem using the anomalous scattering of cadmium and the derivation of a model structure. Scientia Sinica 1984; 27:572-582.

  10. Hua Q and Wang JH. A new method for determining protein structure in solution: The 2DNMR technique. Progress in Bicohem. and Biophys (China). 1984; 3: 2-9

  11. Lewis M, Wang JH. Molecular polarity in DNA-protein recognition. Scientia Sinica 1985; B28:244-246.

  12. Lewis M, Wang JH, Pabo CO. Structure of the operator binding domain of lambda-repressor. In: (Jurnak & McPherson, eds), Structure of Biological Macromolecules and Assemblies, Wiley & Sons, 1985; 2:266-287.

  13. Wang JH*. Protein structure and gene structure. The chemistry of life. (China) 1985; 5:3-4.

  14. Wang JH. Major groove or minor groove. Nature 1986; 319:183-184.

  15. Zhang XJ, Wang JH*. The sequence homology of trichosanthin and ricin A chain. Nature 1986; 321:477-478.

  16. Wang JH. The major groove of B-DNA is the best binding site for the recognition helix of protein. J Biochem (China) 1986; 2:9-12.

  17. Stuart D, Liang DC, Dai JB, Todd R, Lou MZ, You JM, Li JY, Wang JH. The solution of the structure of monomeric insulin derivative by the use of anomalous scattering from thenative crystal. In: Structural biological applications of X-ray absorption, scattering and diffraction, Academic Press. 1986; 315-328.

  18. Pan KZ et al. The three dimensional structure of trichosanthin molecule. Scientia Sinica 1987; B30:386-391.

  19. Ma XQ, Wang YP, Wang JH. An X-ray analysis of the orthorhombic crystal form of trichosathin at 5A. Scientia Sinica 1987; B30:692-697.

  20. Wang JH*. How to design and modify protein molecules. In Progress in Biochem. and Biophys. (China) 1988; 2:144-145.

  21. Wang JH*, Dong YC. Trichosanthin: from Chinese herb medicine to ribosome inactivating protein. In: (Tsou CL, ed) Current Biochemical Research in China, Academic Press, 1989; 25-37.

  22. Wang JH*. DNA topoisomerase. In: Gene regulation and enzymology in biotechnology. Academic Press: China, 1990; 123-141.

  23. Wang JH, Yan Y, Garrett T, Liu J, Rodgers D, Garlick RL, Tarr GE, Husain Y, Reinherz EL, Harrison SC. Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains. Nature 1990; 348:411-418.

  24. Feng Z, Li WW, Yeung HW, Chen SZ, Wang YP, Lin XY, Dong YC, Wang JH. Crystals of alpha-mormorcharin, a new ribosome-inactivating protein. J Mol Biol. 1990; 214:625-626.

  25. Harrison SC, Wang JH, Yan YW, Garrett T, Liu JH, Moebius U, Reinherz EL. Structureand interaction of CD4. Cold Spring Harbor Symp. on Quant. Biol. #57, CSH Laboratory Press, 1992; 541-548.

  26. Harrison SC, Wang JH, Yan YW, Garrett T, Liu JH, Moebius U, Reinherz EL. Structureand interactions of CD4. Proc. of Novo Nordisk Foundation Symp. No. 6 Leukocyte Adhesion, Basic and Clinical Aspects (Gahmberg CG, Mandrup-Poulsen T, Wogensen Bach L, Hokfelt B, eds), Holland: Elsevier, 1992; 449-473.
  27. Garrett TPJ, Wang JH, Yan YW, Liu JH, Harrison SC. Refinement and analysis of the structure of the first two domains of CD4. J Mol Biol. 1993; 234:763-778.

  28. Wang JH, Perpinsky RB, Karpusas M, Lin JH, Osborn L. Crystallization and preliminary crystallographic studies on N-terminal two domain fragment of VCAM-1. Proteins: Struct. Funct. Genet. 1994; 20:287-290.

  29. Wang JH, Perpinsky RB, Stehle T, Liu JH, Karpusas M, Browning B, Osborn L. Crystal structure of an N-terminal two domain fragment of VCAM-1: a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1/α4 integrin interaction. Proc Natl Acad Sci USA 1995; 92:5714-5718.

  30. Karpusas M, Hsu YM, Wang JH, Thompson J, Lederman S, Chess L, Thomas D. 2Å crystal structure of an extracellular fragment of human CD40 ligand. Structure 1995; 3:1031-1039.

  31. Wang JH, Stehle T, Pepinsky RB, Liu JH, Karpusas M, Osborn L. The crystal structure of a functional fragment of VCAM-1 refined at 1.9Å resolution. Acta Cryst. 1996; D52: 369-379.

  32. Liu J,Tse AGD, Chang HC, Liu JH, Wang JH, Hussey RE, Chishti Y, Reinhold B, Spoerl R, Nathenson SG, Sacchettini JC, Reinherz EL. Crystallization of a deglycosylated T cell receptor (TCR) complexed with an anti-TCR Fab fragment. J Biol Chem. 1996; 271: 33639-33646.

  33. Wang, J-H, Casasnovas, J., Springer, T. Liu, J-H. and Harrison SC. The crystal structure of ICAM-2, its comparison to other integrin-binding proteins. Acta Crystallographica A, 1996; 52 (a1): C216-C216. DOI:10.1107/S010876739609071X

  34. Tan K, Liu J-H, Wang J-H, Shen S, Lu M. Atomic structure of a thermostable subdomain of HIV gp41. Proc. Natl. Acad. Sci. USA. 1997; 94:12303-12308.

  35. Casasnovas JM, Springer TA, Liu JH, Harrison SC, Wang JH. The crystal structure of ICAM-2 reveals a distinctive integrin recognition site. Nature 1997; 387:312-315.

  36. Wang J-H, Lim K, Smolyar A, Teng M-K, Liu J-H, Tse AGD, Liu J, Hussey RE, Chishti Y, Thomson CT, Sweet RM, Nathenson SG, Chang H-C, Sacchettini JC, Reinherz EL. Atomic structure of an αβ T cell receptor (TCR) heterodimer in complex with an anti-TCR Fab fragment derived from a mitogenic antibody. EMBO J. 1998; 271:278-293.

  37. Teng M-K, Smolyar A, Tse AGD, Liu J-H, Liu J, Hussey RE, Nathenson SG, Chang H-C, Reinherz EL, Wang J-H. Crystal structure of the N15 TCR in complex with its peptide/MHC (pMHC) ligand: Identification of a common docking topology with substantial variation among different TCR-pMHC complexes. Curr Biol. 1998; 8:409-412.

  38. Casasnovas JM, Stehle T, Liu JH, Wang JH, Springer TA. A dimeric crystal structure for the N-terminal two domains of ICAM-1. Proc. Natl. Acad. Sci. USA. 1998; 95:4134-39

  39. Tan K, Casasnovas JM, Liu J-H, Briskin MJ, Springer TA, Wang J-H. The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition. Structure. 1998; 6:793-801.

  40. Ghendler Y, Teng M-K, Liu J-H, Witte T, Liu J, Kim KS, Kern P, Chang H-C, Wang J-H, Reinherz EL. Differential thymic selection outcomes stimulated by focal structural alteration in peptide/MHC ligands. Proc Natl Acad Sci USA, 1998; 95:10061-10066.

  41. Kern PS, Teng M-K, Smolyar A, Liu J-H, Liu J, Hussey RE, Spoerl R, Chang H-C, Reinherz EL, Wang J-H. Structural basis of CD8 co-receptor function revealed by crystallographic analysis of a murine CD8αα ectodomain fragment in complex with H-2Kb. Immunity 1998; 9:519-530.

  42. Wang J-H*, Springer TA*. Structural specializations of immunoglobulin superfamilymembers for adhesion to integrins and viruses. Immunol Rev. 1998; 163: 197-215.

  43. Wang JH*, The insulin connection: Dorothy Hodgkin and the Beijing Insulin Group. Trends in Biochem. Sci. 1998; 23: 497-500

  44. Wang JH, Smolyar A, Tan K, Liu JH, Kim M, Sun ZJ, Wagner G, Reinherz EL. Structure of a heterophilic adhesion complex between human CD2 and CD58 (LFA-3) counter-receptors. Cell 1999; 97:791-803.

  45. Green N, Rosebrook J, Cochran N, Tan K, Wang J-H, Springer TA, Briskin MJ. Structural analysis of MAdCAM-1/a4b7 interactions reveals significant binding determinants in both the first and second immunoglobulin domains. Cell Adhesion and Communication, 1999; 7:167-181.

  46. Reinherz EL, Tan K, Tang L, Kern P, Liu J-H, Xiong Y, Hussey RE, Smolyar A, Hare B, Zhang R, Joachimiak A, Chang H-C, Wagner G, Wang J-H. The structure of a T cell receptor in complex with peptide and MHC class II. Science 1999; 286:1913-1921.

  47. Sasada T, Ghendler Y, Wang J-H, Reinherz EL. Thymic selection is influenced by subtle structural variation involving the p4 residue of an MHC class I-bound peptide. Eur J Immunol. 2000; 30:1281-1289.

  48. Taraszka KS, Higgins JMG, Tan K, mandelbrot DA, Wang J-H, Brenner MB. Molecular basis for leukocyte integrin αEβ7 adhesion to epithelial (E-) cadherin. J Exp Med. 2000; 191:1555-1567.

  49. Higgins JMG, Cernadas M, Tan K, Irie A, Wang J-H, Takada Y, Brenner MB. The role of α and β chains in integrin recognition by β7 integrins. J Biol Chem. 2000; 275: 25652-25664.

  50. Wang J-H*, Reinherz EL*. Structural basis of cell-cell interactions in the immune system. Curr Op Struct Biol. 2000; 10:656-661.

  51. Wang J-H, Meijers R, Xiong Y, Liu J-H, Sakihama T, Zhang R, Joachimiak A, Reinherz EL. Crystal structure of the human CD4 N-terminal two domain fragment complexed to a class II MHC molecule. Proc Natl Acad Sci USA 2001; 98:10799-10804.

  52. Kim MK, Sun Z-Y J, Byron O, Campbell G, Wagner G, Wang J-H, Reinherz EL. Molecular dissection of the CD2-CD58 counterreceptor interface identifies CD2 Tyr86 and CD58 Lys34 residues as the functional 'hot spot'. J Mol Biol. 2001; 312:711-20.

  53. Wang J-H*, Reinherz EL*. Structural basis of T cell recognition of peptides bound to MHCmolecules. Mol Immunol. 2001; 38:1039-1049.

  54. Sasada T, Touma M, Chang H-S, Clayton LK, Wang J-H, Reinherz EL. Involvement of the TCR Cβ FG loop in thymic selection and T cell function. J Exp Med. 2002; 195: 1419-31.

  55. Jing H, Takagi J, Liu J-H, Lindgren S, Zhang R, Joachimiak A, Wang J-H, Springer TA. Archaeal surface layer proteins contain β propeller, PKD and β helix domains and are related to metazoan cell surface proteins. Structure 2002; 10:1453-1464.

  56. Wang J-H*.  Protein recognition by cell surface receptors: physiological receptors versusvirus interactions. Trends in Biochemical Sciences. 2002; 27:122-126.

  57. Tan K., Zelus BD, Meijers R, Liu J-H, Bergelson JM, Duke N, Zhang R, Joachimiak A, Holmes KV, Wang J-H. Crystal structure of murine sCEACAM1a[1,4]: a coronavirus receptor in the CEA family. EMBO J. 2002; 21:2076-2086.

  58. Tan K, Duquette M, Liu J-H, Dong Y, Zhang R, Joachimiak A, Lawler J, Wang J-H. Crystal structure of the TSP-1 type 1 repeats: A novel layered fold and its biological implication. J Cell Biol. 2002; 159:373-382.

  59. T. A. Springer, M. Shimaoka, Chafen Lu, Tsan Xiao, C. Carman, A. Salas, Jia-huai Wang, Jin-huan Liu, Yuting Yang, S. Blacklow, N. Beglova, J. Takagi , Conformational activation of 2 integrins, their I domains, and regulation by small molecule antagonists, 01/2002; 1. DOI:10.1109/IEMBS.2002.1137041

  60. Sasada T, Yang Y, Lai C-C, Clayton LK, Liu J-H, Parisini E, Wang J-H, Reinherz EL. Disparate peptide-dependent thymic selection outcomes in β2M versus• TAP-1 deficient mice: Implications for repertoire formation. Eur J Immunol. 2003; 33:368-380.

  61. Liu Y, Xiong Y, Naidenko OV, Liu J-H, Zhang R, Joachimiak A, Kronenberg M, Cheroutre H, Reinherz EL, Wang J-H. The crystal structure of a TL/CD8αα complex at 2.1 resolution: Implications for modulation of T cell activation and memory. Immunity 2003; 18:205-215.

  62. Shimaoka M, Xiao T, Liu J-H, Yang Y, Dong Y, Jun C-D, McCormack A, Zhang R, Joachimiak A, Takagi J, Wang J-H, Springer TA. Structures of the aL I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation. Cell 2003; 112: 99-111.

  63. Takagi J, Yang Y, Liu J-H, Wang J-H, Springer TA., Complex between nidogen and laminin fragments reveals a paradigmatic β-propeller interface. Nature 2003; 424: 969-974.

  64. Wang, J-H, Eck, MJ. Assembling atomic resolution views of the immunological synapse. Current Opinion in Immunol. 2003; 15: 286-293.

  65. Springer TA*, Wang J-H*., The three-dimensional structure of integrins and their ligands, and conformational regulation of cell adhesion. Advances in Prot. Chem. 2004; Volume 68 ed. Garcia, K. C., Elsevier, San Diego, CA. pp 29-63.

  66. Wang J-H*., Molecular mechanism of cell-cell recognition. Progress in Biochem.. and Biophys., 2004; 31: 385-392.

  67. Yang Y, Jun C-D, Liu J-H, Zhang R, Jochimiak, A, Springer TA, Wang J-H. Structural basis for dimerization of ICAM-1 on the cell surface. Mol. Cell. 2004, 14:269-276.

  68. Xiao T, Takagi J, Coller BS, Wang J-H, Springer TA. Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen. Nature, 2004; 432: 59-67.

  69. Springer TA, Takagi J, Coller BS, Wang JH, Xiao T, Blood, 2004; 104: 97A-97A. Crystal structure of the integrin alpha IIB beta 3 headpiece at 2.7-3.1 angstrom: Structure, mechanisms of activation and ligand binding, inhibition by eptifibatide, tirofiban, and mAb 10E5, and structure of the HPA-1 alloantigen epitope.

  70. Qiao Z, Kim M, Reinhold B, Montefiori D, Wang J-H, Reinherz EL. Design, expression and immunogenicity of a soluble HIV trimeric envelope fragment adopting a prefusion gp41 configuration. J Biol Chem. 2005; 280:23138-23146.

  71. Song G, Yang Y, Liu J-H, Casasnovas JM, Shimaoka M, Springer TA, Wang J-H. Atomic resolution view of ICAM recognition revealed in a 1.65Å structure of a complex between the binding domains of ICAM-3 and integrin αLβ2. Proc Natl Acad Sci USA. 2005; 102: 3366-3371

  72. Attinger A, Devine L, Wang-Zhu, Y, Martin, D, Wang J. H, Reinherz EL, Kronenberg M, Cheroutre H, Kavathas P. Molecular basis for the high affinity interaction between the thymic leukemia antigen and the CD8αα molecule. J Immunol., 2005; 174: 3501-7

  73. Meijers R, Lai C-C, Yang Y, Liu J-H, Zhong W, Wang J-H, Reinherz EL. Crystal structures of murine MHC class I H-2 Db and Kb molecules in complex with CTL epitopes from influenza A virus: Implications for TCR repertoire selection and immunodominance. J. Mol. Biol., 2005; 345: 1099-1110.

  74. Chang HC, Tan K, Ouyang J, Parisini E, Liu J-H, Le L, Wang X, Reinherz EL, Wang J-H. Structural and mutational analyses of a CD8αβ heterodimer and comparison with CD8αα homodimer. Immunity, 2005; 23: 661-671

  75. Tan K, Duquette M, Liu J-H, Zhang R, Joachimiak A, Wang J-H, Lawler J. The Structures of the Thrombospondin-1 N-terminal domain (TSPN-1) and its complex with a synthetic Pentameric Heparin. Structure, 2006; 14: 33-42

  76. Meijers R, Puettmann-Holgado R, Skiniotis G, Liu J-H, Walz T, Wang J-H, Schmucker D., Structural Basis of Dscam Isoform specificity, Nature, 2007; 449: 487-491

  77. Parisini E, Higgins JMG, Liu J-H, Brenner MB, Wang J-H. The crystal structure of human E-cadherin domains 1 and 2, and comparison with other cadherins in the context of adhesion mechanism, J. Mol. Biol., 2007; 373: 401-411

  78. Wang J-H*, Mallis R.J. and Reinherz, E.L*., Immunodominant-peptide recognition: Betatesting TCRαβ. Immunity, 2008; 28: 139-141

  79. Tan K, Duquette M, Liu J-H, Shanmugasundaran K, Joachimiak A, Gallagher JT, Rigby AC, Wang J-H and Lawler J. Heparin-induced cis- and trans-dimerization modes of the thrombospondin-1 N-terminal domain. J. Biol. Chem. 2008, 283: 3932-3941

  80. Sun ZYJ, Oh KL, Kim M, Yu J, Brusic V, Song L, Qiao Z, Wang J-H, Wagner G, Reinherz EL. HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane. Immunity, 2008, 28: 52-63

  81. Grotenbreg GM, Roan NR, Guillen E, Meijers R, Wang J-H, Bell GW, Starnbach MN, Ploegh HL. Discovery of CD8+ T-cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers. Proc Natl Acad Sci USA. 2008; 105: 3831-35, PMC2268777

  82. Ng A., Zhang H., Tan K., Li Z., Liu J-H., Chan P., Li S-M., Chan W-Y., Au S., Joachimiak A., Walz T., Wang J-H., Shaw P-C. Structure of the influenza H5N1 nucleoprotein: implications for RNA binding, oligomerization and vaccine design. FASEB J., 2008, 22: 3638-3647, PMC2537428

  83. Tan K., Duquette M., Liu J-H., Joachimiak A., Lawler J., Wang J-H., The Crystal Structure of the Heparin-binding Reelin-N Domain of F-spondin. J. Mol. Biol., 2008; 381: 1213-1223, PMC2561254

  84. Zhang H., Casasnovas JM., Jin M., Liu J-H., Gamberg CG., Springer TA., Wang J-H., An unusual allosteric mobility of the C-terminal helix of a high affinity αL integrin I domain variant bound to ICAM-5. Mol. Cell, 2008; 31: 432-437, PMC2603608

  85. Zhang H., Astrof NS.,Liu J-H., Wang J-H., Shimaoka M., Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems. FASEB J., 2009; 23: 2735-40, PMC2717780

  86. Song L., Sun Z-Y., Coleman KE., Zwick MB., Gach JS., Wang J-H., Reinherz EL., Wagner G., Kim M., Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface, Proc Natl Acad Sci USA., 2009; 106: 9057-62, PMC2690059

  87. Zhang H., Liu J-H, Yang W, Springer T., Shimaoka M. and Wang J-H*., Structural basis of activation-dependent binding of a ligand mimetic antibody AL-57 to integrin LFA-1. Proc Natl Acad Sci USA., 2009; 106: 18345-50, PMC2775275

  88. Ng AK-L., Wang J-H., Shaw P-C*., Structure and sequence analysis of influenza A virus nucleoprotein, Science in China Series C: Life Sciences, 2009, 52: 439-449

  89. Jia-huai Wang*, The China connection: Michael Rossmann and his first encounter with me, Protein & Cell, 2010; 1: 6-8

  90. Chan WH, Ng AK, Robb NC, Lam MK, Chan PK, Au SW, Wang JH, Fodor E, Shaw PC. Functional analysis of influenza H5N1 nucleoprotein tail loop reveals amino acids that are crucial for oligomerization and ribonucleoprotein activities. J Virol. 2010; 84: 7337-45, PMC2898228

  91. Zhou B, Chen Q, Mallis R, Zhang H, Liu J-H, Reinherz EL, Wang J-H*. A conserved hydrophobic patch on Vß domains revealed by TCRß chain crystalstructures: implications for pre-TCR dimerization. Frontiers in Immunology, 2011; 2: 1-9, doi: 10.3389/fimmu. 2011.00005, PMC3341985

  92. Kim M, Sun Z-Y J, Rand KD, Shi X, Song L, Cheng Y, Fahmy AF, Majumdar S, Ofek G, Yang Y, Kwong PD, Wang J-H, Engen JR, Wagner G and Reinherz EL., Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization. Nature Struct. & Mol. Biol., 2011; 18: 1235-1243. PMC3253551

  93. Wang J-H and Reinherz E. L. A new angle on TCR activation, Immunity, 2011; 35: 658-660, PMC 3371662

  94. Andy Ka-Leung Ng, Mandy Ka-Han Lam, Hongmin Zhang, Jinhuan Liu, Shannon Wing-Ngor Au, Paul Kay-Sheung Chan, Jiahuai Wang* and Pang-Chui Shaw*, Structural basis for RNA-binding and homo-oligomer formation by influenza B virus nucleoprotein, J Viol. 2012; 86: 6758-6767, PMC3393550

  95. Wang, J-H*., Pull and push: Talin activation for integrin signaling. Cell Research, 2012; 22: 1512-1514, PMC3494393

  96. Thomas Schurpf, Qiang Chen, Jin-huan Liu, Rui Wang, Timothy A. Springer, and Jia-huai Wang. The RGD finger of Del-1 is a unique structural feature critical for integrin inding. The FASEB Journal, 2012; 26: 3412-20

  97. Zhang, H. and Wang, J-H*., Protein expression and purification of integrin I domains and IgSF ligands for crystallography. Method in Molecular Biology 2012; 757: 101-110 (Shimaoka, M. Ed.) Springer

  98. Wang, J-H., Toms A., Zhou M-M., Eck MJ., Protein architecture: Relationship of form and function., Chaptor 5 in Hematology: Basic Principles and Practice. 6th edition, Edited by Ronald Hoffman, Edward, J. Benz, Jr., et al. Elsevier Publisher, 2012, pp 48-54

  99. Wang, J-H. and Reinherz, E.L. The structural basis of αβ T lineage immune recognition: TCR docking topologies, mechanotransduction and co-receptor function. Immunological Review, 2012; 250: 102-119, PMCID: PMC3694212

  100. Qiang Chen, Xiaqin Sun, Xiao-hong Zhou, Jin-huan Liu, Jane Wu, Yan Zhang and Jia-huai Wang. N-terminal horseshoe conformation of DCC is functionally required for axon guidance and may be shared by other neural receptors. J. Cell Science, 2013; 126: 186-195, PMC3603515

  101. Wang, J-H & Reinherz, EL., Revisiting the putative TCR Cα dimerization model through structural analysis. Front Immunol. 2013; 4:16. PMC3558723

  102. Yu, Y., Zhu, J., Huang, P-S., Wang, J-H., Pullen, N., and Springer, TA., Domain 1 of mucosal addressin cell adhesion molecule has an I1-set fold and a flexible integrin-binding loop. J. Biol. Chem. 2013; 288: 6284-6294. PMC3585063

  103. Wang, J-H*., The sequence signature of an Ig-fold, Protein & Cell, 2013; 4: 569-572, PMID: 23842991

  104. Li, X-L, Teng, M, Reinherz, EL, Wang, J-H*, Strict major histocompatibility complex (MHC) molecule class-specific binding by co-receptors enforces MHC-restricted aßTCR recognition during T lineage subset commitment. Front. Immunol, 2013 Nov 22; 4:383 eCollection. PMC3838227

  105. Finci L, Krüger N, Sun X, Zhang J, Chegkazi M, Wu Y, Schenk G, Mertens HDT, Svergun DI,  Zhang Y, Wang J-H* and Meijers R., The crystal structure of netrin-1 in complex with DCC reveals the bi-functionality of netrin-1 as a guidance cue. Neuron, 2014, 83:839-849

  106. Gelfand, MV., Hagan, N., Tata, A., Oh, W-J., Lacoste B., Kang, K-T., Kopycinska J., Bischoff, J., Wang, J-H., Gu C., Neuropilin-1 controls developmental angiogenesis by regulating VEGFR2 independent of VEGF-Neuropilin-1 binding, eLife, 2014, DOI: http://dx.doi.org/10.7554/eLife.03720, PMC4197402

  107. Liu, Y., Zhang, Y., Wang, J-H., Crystal structure of human Ankyrin G death domain, PROTEINS: Structure, Function, and Bioinformatics, 2014; 82: 3476-82, PMCID: PMC4258306

  108. Wang, J-H., The immunology connection – My first T cell receptor structure projects, Protein & Cell, 2014; 5: 12-14. PMCID: PMC4145086

  109. Reinherz EL and Wang J-H, Codification of bidentate pMHC interaction with TCR and its co-receptor, Trend in Immunology, 2015; 36:300-6, PMID: 25818864

  110. Finci, L, Zhang, Y, Meijers, R and Wang J-H . Signaling mechanism of netrin-1 receptor DCC in axon guidance, Progress in Biophysics and Molecular Biology, 2015; 118: 153-60, PMID: 25881791

  111. Chou, J. and Wang, J-H., Editorial Comments: Transmembrane Signaling: A Multiplex Problem With Converging Solutions. Progress in Biophysics and Molecular Biology, 2015; 118: 87-8

  112. Kumar Das, D, Feng Y, Mallis RJ., Li X., Keskin, DB., Hussey RE., Brady SK., Wang J-H., Wagner G., Reinherz EL., Lang MJ., Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime, PNAS, 2015, 112: 1517-22, PMC4321250

  113. Chen X., Zhao C., Li, X-L., Wang, T., Li Y., Cao. C., Ding, Y., Dong, M., Finci, L., Wang L-H*., Li, X. and Liu. L.  Terazosin can activate Pgk1 and Hsp90 to promote stress resistance, Nature, Chem. Biol., 2014; in press

  114. Mallis RJ, Bai K, Arthanari H, Hussey RE, Handley M, Li Z, Chingozha L, Duke-Cohan JS, Lu H, Wang JH, Zhu C, Wagner G, Reinherz EL., Pre-TCR ligand binding impacts thymocyte development before αβTCR expression. Proc Natl Acad Sci U S A, 2015; 112:8373-8, PMID 26056289

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