Structures

Immunology  •  Adhesion  •  Virology  •  Matrix  •  Neuroscience



Virus receptors

1) CD4: HIV receptor
PDB: 2CD4
These are N-terminal domains 1 and 2. Phe43 is the key binding residue.
Nature, 1990; 348: 411-418

2) ICAM-1: Human rhinovirus receptor
PDB: 1IC1
These are the N-terminal domains 1 and 2. The residues in red color are responsible for virus binding
PNAS, 1998; 95: 4134-4139

3) MHVR: Mouse hepatitis virus receptor
These are the spliced domains 1 and 4 of protein called sCEACAM1a. Ile41 is the key binding residue.
EMBO J., 2002; 21: 2076-2086

4) VCAM-1: Receptor for encephalomyocarditis virus on murine
PDB: 1VSC
These are the domains 1 and 2 of a cell adhesion molecule, which is the ligand for integrin α4β1. Residues in red color are possible virus-binding part. Possible integrin-binding region is the CD loop of domain 1
PNAS, 1995; 92: 5714-5718



Fusion peptide of HIV glycoprotein gp41

PDB: 1SZT
This is post-fusion conformation of the peptide N34(L6)C28.
PNAS, 1997; 94: 12303-12308


Nucleoprotein of influenza virus H5N1

The Arg-pit is the RNA-binding site
PDB: 2QP6
FASEB J. 2008; 22: 3638-3647

site design by Miao