Essays  •  Major Publications  •  Complete List of Publications  •  Reviews

Major publications during 1999-2013:

  1. Chen X., Zhao C., Li, X-L., Wang, T., Li Y., Cao. C., Ding, Y., Dong, M., Finci, L. Wang J-H*., Li, X. and Liu. L.  Terazosin can activate Pgk1 and Hsp90 to promote stress resistance, Nature, Chem. Biol., 2014; in press

  2. Finci L, Krüger N, Sun X, Zhang J, Chegkazi M, Wu Y, Schenk G, Mertens HDT, Svergun DI,  Zhang Y, Wang J-H* and Meijers R., The crystal structure of netrin-1 in complex with DCC reveals the bi-functionality of netrin-1 as a guidance cue. Neuron, 2014, 83:839-849

  3. Qiang Chen, Xiaqin Sun, Xiao-hong Zhou, Jin-huan Liu, Jane Wu, Yan Zhang and Jia-huai Wang. N-terminal horseshoe conformation of DCC is functionally required for axon guidance and may be shared by other neural receptors. J. Cell Science, 2013; 126: 186-195

  4. Thomas Schurpf, Qiang Chen, Jin-huan Liu, Rui Wang, Timothy A. Springer, and Jia-huai Wang. The RGD finger of Del-1 is a unique structural feature critical for integrin inding. The FASEB Journal, 2012; 26: 3412-20

  5. Wang, J-H. and Reinherz, E.L. The structural basis of ab T lineage immune recognition: TCR docking topologies, mechanotransduction and co-receptor function. Immunological Review, 2012; 250: 102-119

  6. Meijers R, Puettmann-Holgado R, Skiniotis G, Liu J-H, Walz T, Wang J-H, Schmucker D., Structural Basis of Dscam Isoform specificity, Nature, 2007; 449: 487-491

  7. Chang HC, Tan K, Ouyang J, Parisini E, Liu J-H, Le L, Wang X, Reinherz EL, Wang J-H. Structural and mutational analyses of a CD8αβ heterodimer and comparison with CD8αα homodimer. Immunity, 2005; 23: 661-671

  8. Song G, Yang Y, Liu J-H, Casasnovas JM, Shimaoka M, Springer TA, Wang J-H. Atomic resolution view of ICAM recognition revealed in a 1.65Å structure of a complex between the binding domains of ICAM-3 and integrin αLβ2. Proc Natl Acad Sci USA. 2005; 102: 3366-3371

  9. Xiao T, Takagi J, Coller BS, Wang J-H, Springer TA. Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen. Nature, 2004; 432: 59-67

  10. Yang Y, Jun C-D, Liu J-H, Zhang R, Jochimiak, A, Springer TA, Wang J-H. Structural basis for dimerization of ICAM-1 on the cell surface. Mol. Cell. 2004, 14:269-276.

  11. Springer TA, Wang J-H., The three-dimensional structure of integrins and their ligands, and conformational regulation of cell adhesion. Advances in Prot. Chem. 2004; Volume 68 ed. Garcia, K. C., Elsevier, San Diego, CA. pp 29-63.

  12. Shimaoka M, Xiao T, Liu J-H, Yang Y, Dong Y, Jun C-D, McCormack A, Zhang R, Joachimiak A, Takagi J, Wang J-H, Springer TA. Structures of the aL I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation. Cell 2003; 112: 99-111.

  13. Wang J-H. Protein recognition by cell surface receptors: physiological receptors versus virus interactions. Trends in Biochemical Sciences. 2002; 27:122-126.

  14. Tan K, Duquette M, Liu J-H, Dong Y, Zhang R, Joachimiak A, Lawler J, Wang J-H. Crystal structure of the TSP-1 type 1 repeats: A novel layered fold and its biological implication. J Cell Biol. 2002; 159:373-382.

  15. Tan K., Zelus BD, Meijers R, Liu J-H, Bergelson JM, Duke N, Zhang R, Joachimiak A, Holmes KV, Wang J-H. Crystal structure of murine sCEACAM1a[1,4]: a coronavirus receptor in the CEA family. EMBO J. 2002; 21:2076-2086.

  16. Wang J-H, Meijers R, Xiong Y, Liu J-H, Sakihama T, Zhang R, Joachimiak A, Reinherz EL. Crystal structure of the human CD4 N-terminal two domain fragment complexed to a class II MHC molecule. Proc Natl Acad Sci USA 2001; 98:10799-10804.

  17. Reinherz EL, Tan K, Tang L, Kern P, Liu J-H, Xiong Y, Hussey RE, Smolyar A, Hare B, Zhang R, Joachimiak A, Chang H-C, Wagner G, Wang J-H. The structure of a T cell receptor in complex with peptide and MHC class II. Science 1999; 286:1913-1921.

  18. Wang JH, Smolyar A, Tan K, Liu JH, Kim M, Sun ZJ, Wagner G, Reinherz EL. Structure of a heterophilic adhesion complex between human CD2 and CD58 (LFA-3) counter-receptors. Cell 1999; 97:791-803.

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